Endocrine Abstracts

Background: The higher prevalence of urinary albumin was reported in patients with primary aldosteronism (PA) than those with essential hypertension (EH). It remains to be unclear, although ‘glomerular hyperfiltration (HF)’ was hypothesized as one of the mechanisms of urinary albumin.Objectives: To clarify the risk factor of urinary albumin and the relationship with HF in PA.Methods: 123 patients with PA were treated acco...

Context: 18-Oxocortisol (18-oxoF) is a derivative of cortisol that is produced by aldosterone synthase (CYP11B2). The potential for this steroid, as a biomarker for differentiating patients with aldosterone-producing adenoma (APA) from those with idiopathic hyperaldosteronism (IHA), has not been examined.Objectives: We measured 18-oxoF, aldosterone (A) and cortisol (F) in plasma from adrenal vein sampling (AVS) patients. We compared 18-oxoF and 18-oxoF/F...

18-Oxocortisol (18-oxoF) is a derivative of cortisol (F) that is produced by aldosterone synthase (CYP11B2), and its clinical usefulness has not been clarified. We prospectively measured 18-oxoF, using highly sensitive liquid chromatography-tandem mass spectrometry (LC/MS/MS), in peripheral plasma of patients with primary aldosteronism (PA) who underwent adrenal venous sampling (AVS) to differentiate aldosterone producing adenoma (APA) from bilateral hyperplasia. The study was...